Evaluation of the Contractile State of the Human Heart from the First Derivative
نویسنده
چکیده
The first derivatives of the left ventricular pressure pulse (dp/dt LV) and of the apexcardiogram (A ACG) were recorded 73 times in 45 subjects, and the time intervals from the peak of the R wave of the electrocardiogram to the peak of the derivatives (t-dp/dt LV and t-A ACG) were determined under different circulatory conditions. These parameters express the duration of the development of maximum tension during isometric contraction of the ventricle. The values obtained from the left ventricular pressure pulse and from the ACG showed close correlation both at rest and after pharmacological interventions which enhanced or depressed the myocardial contractile state. During orciprenaline infusion, t-dp/dt LV and t-A ACG were consistently shortened, while they increased in most cases after beta-adrenergic receptor blockade. Determination of the time to peak derivative of the ACG, a parameter so far unexplored, is proposed as a simple method of detecting changes in the myocardial contractile state in the intact human being.
منابع مشابه
Evaluation of the contractile state of the human heart from the first derivative of the apexcardiogram.
متن کامل
Evaluation of the Contractile State of the Human Heart from the First Derivative
The first derivatives of the left ventricular pressure pulse (dp/dt LV) and of the apexcardiogram (A ACG) were recorded 73 times in 45 subjects, and the time intervals from the peak of the R wave of the electrocardiogram to the peak of the derivatives (t-dp/dt LV and t-A ACG) were determined under different circulatory conditions. These parameters express the duration of the development of maxi...
متن کاملIdentification and Evaluation of Human Errors in Low Voltage Distribution Systems using FUZZY-HEART Technique
Electricity-related occupational accidents are the fifth leading cause of occupational deaths. One of the major causes of occupational accidents is human error. That is why the human role as a cause of the accident is so important and must be considered during risk assessment. The purpose of this study is to present a Fuzzy-HERAT human error assessment method, which can be used to assess the pr...
متن کاملSynthesis of a peptide derivative of microcin J25 and evaluation of antibacterial and biological activities
Microcin J25 (MccJ25) is a small ribosomally synthesized antimicrobial peptide that is produced by Enterobacteriacea family especially E.coli. The present study focuses on preparation and evaluation of in vitro antimicrobial and biological properties of a new peptide derived from MccJ25. We prepared a MccJ25-derived peptide containing 14 amino acids and a single intra-molecular disulfide bond a...
متن کاملSynthesis of a peptide derivative of microcin J25 and evaluation of antibacterial and biological activities
Microcin J25 (MccJ25) is a small ribosomally synthesized antimicrobial peptide that is produced by Enterobacteriacea family especially E.coli. The present study focuses on preparation and evaluation of in vitro antimicrobial and biological properties of a new peptide derived from MccJ25. We prepared a MccJ25-derived peptide containing 14 amino acids and a single intra-molecular disulfide bond a...
متن کامل